MSDS for Methyl 4-Chloroacetoacetate

Identification

Product Name: Methyl 4-Chloroacetoacetate
Synonyms: 4-Chloroacetoacetic acid methyl ester
Chemical Formula: C5H7ClO3
Molecular Weight: 150.56 g/mol
CAS Number: 638-07-3
Intended Use: Laboratory chemicals, manufacturing intermediates, research and development
Supplier Information: Manufacturer’s name, complete address, emergency phone number, and business contact details typically added by supplier
Emergency Phone: National Poison Control Center or your local emergency response services
Date of MSDS Revision: Refer to current documentation for latest update

Hazard Identification

GHS Classification: Acute Toxicity Oral: Category 4, Skin Irritation: Category 2, Eye Irritation: Category 2A
Hazard Statements: Harmful if swallowed; Causes skin irritation; Causes serious eye irritation
Pictograms: Exclamation mark
Signal Word: Warning
Precautionary Statements: Avoid breathing vapors or dust; Wash skin thoroughly after handling; Wear protective gloves, clothing, eye and face protection; If on skin: wash with soap and water; If in eyes: rinse cautiously with water for several minutes; if exposed or concerned, get medical attention
Symptoms: Irritation or redness of eyes and skin, nausea, abdominal discomfort after swallowing
Environmental Hazard: May pose risk to aquatic environments with long-lasting effects

Composition / Information on Ingredients

Chemical Name: Methyl 4-Chloroacetoacetate
Concentration: 98-100% by weight
Impurities: Trace impurities do not play a significant role in classification
CAS Number: 638-07-3
EC Number: 211-325-5

First Aid Measures

General Advice: Remove contaminated clothing, ensure medical attention is provided
Inhalation: Move affected person to fresh air, keep warm and at rest, seek immediate medical assistance if symptoms persist
Skin Exposure: Wash thoroughly with plenty of water and soap for at least 15 minutes, remove contaminated clothing, seek medical help if irritation appears
Eye Exposure: Rinse eyes gently with water for at least 15 minutes keeping eyelids apart, seek immediate medical attention
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical attention
Most Important Symptoms: Skin and eye irritation, nausea or abdominal pain after ingestion

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Unsuitable Media: No direct jet of water on burning material
Hazards During Fire: May emit toxic fumes of hydrogen chloride, carbon oxides
Protective Equipment: Full protective clothing, self-contained breathing apparatus
Special Procedures: Keep containers cool by spraying with water, remove personnel from risk area, prevent release of contaminated extinguishing water into drains

Accidental Release Measures

Personal Precautions: Ventilate area, avoid breathing vapors or dust, wear suitable protective equipment including gloves, goggles, protective suit, and suitable respirators
Environmental Precautions: Prevent product from entering drains, sewers, water courses, or soil
Containment: Contain spill using non-combustible absorbents such as sand, earth, vermiculite
Cleanup Methods: Collect and place absorbed material in appropriate waste container for disposal; clean spill area with water afterwards and ventilate the area thoroughly; wash down residues and keep out of water supplies

Handling and Storage

Handling: Keep containers tightly closed, use in well-ventilated areas, avoid contact with skin, eyes, and clothing, do not eat, drink, or smoke while using product, handle with appropriate personal protective equipment
Storage Conditions: Store in cool, dry, and well-ventilated area, keep away from sources of ignition or heat, store in original containers or compatible, labeled chemical containers, keep away from incompatible materials (strong oxidizing agents, acids, alkalis)
Incompatibilities: Incompatible with strong acids, bases, and oxidizing agents
Packaging Materials: Use corrosion-resistant, tightly sealed containers; polyethylene-lined steel drums or similar recommended

Exposure Controls and Personal Protection

Engineering Controls: Use in a chemical fume hood, local exhaust ventilation as required to maintain airborne concentrations below recommended limits
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, laboratory coat or apron, closed footwear
Respiratory Protection: Use NIOSH/MSHA approved respirator where exposure limits are exceeded or where ventilation is inadequate
Eye Protection: Splash-proof chemical safety goggles
Hand Protection: Impermeable protective gloves
Hygiene Measures: Avoid eating, drinking, and smoking during handling; wash hands thoroughly; remove contaminated clothing and wash before reuse
Monitoring Procedures: Use standard monitoring equipment to assess workplace air concentrations

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Slight, characteristic odor
Odor Threshold: Not determined
pH: Not applicable (non-aqueous liquid)
Melting Point: -17°C
Boiling Point: 200-202°C
Flash Point: 97°C
Evaporation Rate: Not available
Flammability: Combustible liquid
Upper/Lower Flammability or Explosive Limits: Not determined
Vapor Pressure: 0.13 mmHg @ 25°C
Vapor Density: Not determined
Relative Density: 1.25 g/cm³ @ 20°C
Solubility: Slightly soluble in water, soluble in ethanol, ether, and most organic solvents
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not available
Viscosity: Not available

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions and normal temperatures
Reactivity: No hazardous polymerization expected
Possibility of Hazardous Reactions: May react with strong oxidizers, acids, or bases
Incompatible Materials: Strong oxidizing agents, strong acids or alkalis
Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen chloride, phosgene may be released at high temperatures or on combustion
Conditions to Avoid: Heat, flames, sparks, exposure to moisture, incompatible materials

Toxicological Information

Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Harmful if swallowed, moderately toxic by oral entry, LD50 (rat, oral): ~200-500 mg/kg (estimate based on chemical class)
Skin Corrosion/Irritation: Causes irritation and redness
Serious Eye Damage/Irritation: Produces irritation, redness, tearing, may cause permanent damage with strong exposure
Respiratory Effects: Inhalation of vapors may cause respiratory irritation, discomfort, coughing, and headache
Chronic Effects: Not enough data for chronic toxicity, repeated or prolonged exposure may produce dermatitis or other delayed effects
Carcinogenicity: No component listed as carcinogen by IARC, NTP, or OSHA
Mutagenicity, Teratogenicity, Reproductive Toxicity: Insufficient data
Other Effects: Sensitization unlikely but possible; chemical burns possible with heavy exposure

Ecological Information

Ecotoxicity: Harmful to aquatic life with potential for long-term adverse effects
Persistence and Degradability: Not rapidly biodegradable, chemical may remain in soil and water for prolonged periods
Bioaccumulative Potential: Potential for bioaccumulation exists due to chemical’s stability and physicochemical properties
Mobility in Soil: Low mobility expected; will adsorb to soil particles
Aquatic Toxicity: Estimated LC50 values for fish and aquatic invertebrates range from 1-10 mg/L (based on structurally related compounds)
Other Adverse Effects: No known ozone depletion, greenhouse gas, or endocrine disrupting properties known

Disposal Considerations

Waste Disposal Methods: Dispose of waste in accordance with local, regional, national, and international regulations; incinerate in a chemical incinerator equipped with afterburner and scrubber
Disposal of Contaminated Packaging: Empty containers should be triple-rinsed, chemically decontaminated if needed, and disposed of as hazardous chemical waste
Precautions: Do not allow product or waste to enter drinking water supplies, sewers, or water courses
Additional Guidance: Work with licensed chemical disposal contractors familiar with organic compound waste streams

Transport Information

UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains Methyl 4-Chloroacetoacetate)
Transport Hazard Class: 6.1
Packing Group: III
Label: Toxic (skull and crossbones), environmental hazard if specified
Marine Pollutant: Yes, based on aquatic toxicity
Special Precautions for User: Segregate from foodstuffs, store upright, ensure containers are sealed and labeled correctly
Transport in Bulk: Regulated per Annex II of MARPOL 73/78 and the IBC Code for maritime bulk shipment; refer to specific vessel and port regulations
Additional Transport Information: Handle using appropriate containment and labeling on all major transit routes, comply with ADR/RID, IMDG, IATA guidelines

Regulatory Information

TSCA: Chemical listed on the US Toxic Substances Control Act Inventory
EINECS/ELINCS: Listed on the European Inventory of Existing Commercial Chemical Substances
REACH Status: Check with supplier for latest registration and pre-registration details under EU REACH regulation
OSHA Hazard Classification: Classified as hazardous according to 29 CFR 1910.1200 (Hazcom 2012)
SARA Title III: Not listed as an extremely hazardous substance; not subject to specific reporting under SARA Section 313
Canadian DSL/NDSL: Ingredients appear on Domestic Substances List
Inventory Listings: Complies with China IECSC, Australia AICS, Japan ENCS, Korea ECL, Philippines PICCS
Label Requirements: Comply with national and international chemical safety labeling requirements including hazard pictograms, warnings, and risk/safety phrases
Other Regulatory Notes: End user responsible for regulatory compliance at point of use; regular updates and review of global hazard communication standards recommended