Material Safety Data Sheet – Ethyl 4-Chloroacetoacetate

Identification

Product Name: Ethyl 4-Chloroacetoacetate
Chemical Formula: C6H9ClO3
Synonyms: Ethyl monochloroacetoacetate
CAS Number: 638-07-3
Use: Often used as an intermediate in organic synthesis, pharmaceutical development, and agrochemical research
Supplier: Contact supplier directly for relevant details on address, emergency contact, and product code
Emergency Phone: Access local or national chemical emergency hotlines to report spills or exposure incidents

Hazard Identification

Classification: Flammable liquids (Category 4); Acute toxicity, oral (Category 4); Eye irritation (Category 2); Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may be harmful in contact with skin or inhaled
Pictograms: Exclamation mark (for irritant hazards)
Precautionary Statements: Wear protective clothing, avoid breathing vapors, use only outdoors or in well-ventilated areas, wash hands thoroughly after handling
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Symptoms of Exposure: Burning sensation in eyes, redness or dryness on skin, nausea or stomach upset if swallowed, coughing or respiratory discomfort if inhaled

Composition / Information on Ingredients

Chemical Name: Ethyl 4-Chloroacetoacetate
Concentration: 97–100%
Impurities: Minimal, typically trace levels of acetic acid derivatives or ethanol
Hazardous Components: Main component is also the hazardous component, no major additives or fillers

First Aid Measures

Inhalation: Move to fresh air at once, monitor breathing, supply oxygen if available, seek immediate medical help if symptoms appear severe
Skin Contact: Rinse skin with lots of water and gentle soap, remove all contaminated clothing, do not rub affected skin, consult a doctor if irritation continues
Eye Contact: Flush eyes gently with water for at least 15 minutes, keep eyelids open, remove contact lenses if present, get emergency medical advice
Ingestion: Rinse mouth thoroughly with water, never induce vomiting, seek urgent medical attention, show product label if possible
Notes for Doctors: Treat symptomatically, observe for delayed effects in the lungs or gastrointestinal system, keep local poison control contacts on hand

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, avoid direct water jets
Unsuitable Media: Water spray may scatter and spread fire, do not use on open chemical pools
Special Hazards: Product vapors can form explosive mixtures with air, combustion releases toxic gases like hydrogen chloride and carbon monoxide
Protective Equipment: Full fire-resistant suit, self-contained breathing apparatus, chemical-resistant gloves
Firefighting Instructions: Isolate hazard area, remove containers if it can be done safely, prevent runoff into sewers or drains, cool exposed containers with water mist

Accidental Release Measures

Personal Protection: Wear goggles, gloves, long-sleeved clothing, respirator suited for organic vapors
Environmental Precautions: Prevent discharge into drains, ditches or water bodies, advise local authorities if significant spill occurs
Cleanup Methods: Ventilate affected area, absorb spills with inert materials like dry sand or vermiculite, collect residues in sealable chemical drums, decontaminate affected surfaces with water and detergent, dispose of all materials in accordance with regulations
Emergency Procedures: Evacuate unnecessary personnel, isolate area, restrict access until cleanup is complete

Handling and Storage

Safe Handling: Handle only in chemical fume hood or well-ventilated workplace, avoid direct bodily contact, keep away from sources of ignition or heat, do not eat, drink or smoke nearby, avoid splashes during transfers
Storage Conditions: Store tightly closed in cool, dry, well-ventilated location, separate from incompatible chemicals such as strong bases, oxidizing agents and acids
Container Requirements: Use corrosion-resistant containers, check for leaks regularly, label everything clearly
Handling Precautions: Do not reuse empty containers except for compatible chemicals, clean thoroughly after each use

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits, adopt strict hygiene practices
Engineering Controls: Install local exhaust ventilation, maintain eyewash stations and safety showers within easy reach, monitor air regularly for vapor concentrations
Personal Protective Equipment (PPE): Splash-resistant goggles, protective gloves such as nitrile or neoprene, chemical-resistant apron, closed shoes, organic vapor respirators where controls are inadequate
Hygiene Measures: Wash thoroughly after handling, keep contaminated clothing out of clean areas, do not eat or drink in the work area

Physical and Chemical Properties

Appearance: Clear or slightly yellow liquid
Odor: Mild ester-like odor
Molecular Weight: 164.59 g/mol
Boiling Point: 108–110°C at 13 mmHg
Melting Point: Not applicable
Flash Point: Approximately 92°C (closed cup)
Solubility: Slightly soluble in water, readily soluble in organic solvents like ethanol, ether, and chloroform
Density: About 1.22 g/cm³
Vapor Pressure: Low at room temperature; vaporizes more quickly at higher temperatures
pH: Not established for aqueous solutions
Evaporation Rate: Slower than ether
Auto-ignition Temperature: Data not available
Partition Coefficient (Log Pow): Data limited, consult supplier’s technical center for measured value

Stability and Reactivity

Chemical Stability: Stable under recommended storage, decomposes on strong heating
Reactivity: Reacts vigorously with strong bases, oxidizing agents, acids, may form hazardous decomposition products on contact with metals
Hazardous Reactions: Intense exotherms may occur with incompatible materials
Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, additional chlorinated compounds
Conditions to Avoid: Exposure to heat, open flame, moisture, strong sunlight, improper storage

Toxicological Information

Acute Toxicity: Estimated LD50 (oral, rat) between 300–2000 mg/kg; inhalation toxicity not thoroughly established; can cause illness if swallowed in small amounts
Skin Corrosion/Irritation: Causes redness, dryness, can be absorbed through skin in harmful amounts
Eye Damage/Irritation: Produces moderate to severe irritation, risk of vision damage in high exposures
Respiratory Irritation: May cause cough, sore throat, or chest discomfort
Long-Term Effects: Limited evidence, though repeated or prolonged exposure may damage liver or kidneys; no strong links to cancer identified; avoid any unnecessary exposure
Sensitization: No definitive reports but some individuals might develop allergies
Mutagenicity: Information sparse, suggest caution for workers of child-bearing age

Ecological Information

Behavior in Environment: Low volatility, moderate mobility in soil, may contaminate groundwater if released
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment; specific LC50 values for fish or invertebrates not widely reported, treat as hazardous
Persistence/Degradability: Slow breakdown in typical environmental conditions, persists unless collected and managed
Bioaccumulative Potential: May moderate accumulation in aquatic food chains, world data incomplete
Additional Notes: Avoid any release into sewers, ditches, or natural waterways, warn local authorities in the event of significant spill

Disposal Considerations

Waste Treatment Methods: Collect unused product or contaminated absorbents in approved waste containers; incinerate in chemical waste facilities with proper emissions treatment
Container Disposal: Rinse adequately, do not release cleaning water to the environment, destroy or recycle through licensed disposal agents
Legal Requirements: Comply with regional, national, and local hazardous waste regulations, obtain waste codes from environmental authorities
Precautions: Avoid landfill unless absolutely required by law, record waste movement and final disposal clearly

Transport Information

Regulatory Status: Classified as a hazardous good for road, sea, and air transport
UN Number: 2810 (Toxic liquid, organic, n.o.s.)
Transport Hazard Class: Class 6.1, toxic substances
Packing Group: III
Proper Shipping Name: Toxic liquid, organic, n.o.s. (Ethyl 4-Chloroacetoacetate)
Emergency Response: Carry appropriate spill control equipment, wear personal protection, follow instructions from local authorities
Special Precautions: Keep containers upright, label with proper hazard designations, avoid temperature extremes during transit

Regulatory Information

Labeling Requirements: According to GHS, product must display hazard pictograms, signal words, and statements
Chemical Inventory Listings: Listed in most international inventories including TSCA (United States), EINECS/ELINCS (Europe), DSL (Canada), AICS (Australia)
Local Rules: Review occupational exposure, storage, and reporting rules per jurisdiction
Restrictions: Some countries may impose import or use restrictions, consult national regulators
Additional Regulations: Observe chemical accident prevention, workplace safety (OSHA/NIOSH), and environmental (EPA/REACH) obligations as updated