Why is Sodium Metabisulfite in EpiPen?

Sodium metabisulfite is included in EpiPen formulations as an antioxidant preservative. Its main purpose is to help maintain the stability and effectiveness of the active ingredient, epinephrine.

  • Prevents Oxidation: Epinephrine is sensitive to oxygen and can degrade quickly when exposed to air. Sodium metabisulfite helps slow this oxidation process, extending the shelf life of the medication.
  • Enhances Potency: Keeping epinephrine stable ensures that it remains effective in treating severe allergic reactions (anaphylaxis) when administered.
  • Preservation: The antioxidant property of sodium metabisulfite helps preserve the solution for use in emergency situations.

Note: Some individuals are sensitive or allergic to sulfites (like sodium metabisulfite). This is noted in the product information for EpiPen, as a small number of users may experience allergic-type reactions.